Chemotherapy-induced differentiation to cure botryoid rhabdomyosarcoma: a case report and review of the literature

T AssiE El RassyG Abi-TayehC Sader-GhorraG AbadjianR EidT MoussaF FarhatJ Kattan

PMID: 29953806

Abstract

Rhabdomyosarcoma (RMS) occurs rarely in adults and constitutes 2-6% of all uterine neoplasms. The authors report the case of a 26-year-old woman diagnosed with botryoid RMS that presented discordant progression results on follow up imaging and cytodifferentiation on pathologic control. This case showed that radiological evaluation could be misleading as the tumor demonstrated chemotherapy-induced differentiation without volume reduction. This case illustrates the limitations of using the imaging anatomical dimensions of sarcomas for treatment planning and highlights the potential role of functional imaging to assess the response to treatment.