Overcoming the resistance to BRAF inhibitor by the double BRAF and MEK inhibitions in advanced melanoma: a case report
Joseph Kattan 1, Clarisse Kattan 1, Fadi Farhat 2, Tarek Assi 2 3
Affiliations
1Hematology-Oncology Department, Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut.
2Hematology-Oncology Department, Hammoud Hospital UMC, Saida.
3Hematology-Oncology Department, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
PMID: 31490286
DOI: 10.1097/CAD.0000000000000827
Abstract
The advent of BRAF and MEK inhibitors changed the landscape of the management of BRAF mutated melanoma patients. In this article, we report the case of a 51-year-old man with BRAF mutated locally advanced cutaneous melanoma of the head who demonstrated a limited response to initial anti-BRAF monotherapy followed by extensive surgery. Anti-PD1 therapy failed to reverse the disease progression. However, subsequent double inhibition of the BRAF and MEK pathways induced a fast and remarkable tumour response.
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